Neutrino-nucleus interactions in the T2K experiment

We present a study of neutrino-nucleus interactions at the T2K experiment based on the GiBUU transport model. The aim of T2K is to measure $\nu_e$ appearance and $\theta_{13}$, but it will also be able to do a precise measurement of $\nu_\mu$ disappearance. The former requires a good understanding of $\pi^0$ production while the latter is closely connected with a good understanding of quasielastic scattering. For both processes we investigate the influence of nuclear effects and particular final-state interactions on the expected event rates taking into account the T2K detector setup.Comment: v3: matches version to be published in Phys. Rev.

Magnitude of visual accommodation to a head-up display

The virtual image symbology of head-up displays (HUDs) is presented at optical infinity to the pilot. This design feature is intended to help pilots maintain visual focus distance at optical infinity. However, the accommodation response could be nearer than optical infinity, due to an individual's dark focus response. Accommodation responses were measured of two age groups of airline pilots to: (1) static symbology on a HUD; (2) a landing site background at optical infinity; (3) the combination of the HUD symbology and the landing site background; and (4) complete darkness. Results indicate that magnitude of accommodation to HUD symbology, with and without the background, is not significantly different from an infinity focus response for either age group. The dark focus response is significantly closer than optical infinity for the younger pilots, but not the older pilots, a finding consistent with previous research

The pion wave function in covariant light-front dynamics

The structure of the pion wave function in the relativistic constituent quark model is investigated in the explicitly covariant formulation of light-front dynamics. We calculate the two relativistic components of the pion wave function in a simple one-gluon exchange model and investigate various physical observables: decay constant, charge radius, electromagnetic and transition form factors. We discuss the influence of the full relativistic structure of the pion wave function for an overall good description of all these observables, including both low and high momentum scales.Comment: 12 pages, 10 figure

Zeros of conformal vector fields and twistor spinors in Lorentzian geometry

We study the zero set of conformal vector fields on Lorentzian manifolds that have properties like the associated conformal vector field of a twistor spinor. We prove that locally the zero set of such conformal vector fields lies on a lightlike smooth geodesic

A sub-product construction of Poincare-Einstein metrics

Given any two Einstein (pseudo-)metrics, with scalar curvatures suitably related, we give an explicit construction of a Poincar\'e-Einstein (pseudo-)metric with conformal infinity the conformal class of the product of the initial metrics. We show that these metrics are equivalent to ambient metrics for the given conformal structure. The ambient metrics have holonomy that agrees with the conformal holonomy. In the generic case the ambient metric arises directly as a product of the metric cones over the original Einstein spaces. In general the conformal infinity of the Poincare metrics we construct is not Einstein, and so this describes a class of non-conformally Einstein metrics for which the (Fefferman-Graham) obstruction tensor vanishes.Comment: 23 pages Minor correction to section 5. References update

Mol. Cell. Proteomics

Chemical cross-linking in combination with mass spectrometric analysis offers the potential to obtain low-resolution structural information from proteins and protein complexes. Identification of peptides connected by a cross-link provides direct evidence for the physical interaction of amino acid side chains, information that can be used for computational modeling purposes. Despite impressive advances that were made in recent years, the number of experimentally observed cross-links still falls below the number of possible contacts of cross-linkable side chains within the span of the cross-linker. Here, we propose two complementary experimental strategies to expand cross-linking data sets. First, enrichment of cross-linked peptides by size exclusion chromatography selects cross-linked peptides based on their higher molecular mass, thereby depleting the majority of unmodified peptides present in proteolytic digests of cross-linked samples. Second, we demonstrate that the use of proteases in addition to trypsin, such as Asp-N, can additionally boost the number of observable cross-linking sites. The benefits of both SEC enrichment and multiprotease digests are demonstrated on a set of model proteins and the improved workflow is applied to the characterization of the 20S proteasome from rabbit and Schizosaccharomyces pombe

Unbounded Human Learning: Optimal Scheduling for Spaced Repetition

In the study of human learning, there is broad evidence that our ability to retain information improves with repeated exposure and decays with delay since last exposure. This plays a crucial role in the design of educational software, leading to a trade-off between teaching new material and reviewing what has already been taught. A common way to balance this trade-off is spaced repetition, which uses periodic review of content to improve long-term retention. Though spaced repetition is widely used in practice, e.g., in electronic flashcard software, there is little formal understanding of the design of these systems. Our paper addresses this gap in three ways. First, we mine log data from spaced repetition software to establish the functional dependence of retention on reinforcement and delay. Second, we use this memory model to develop a stochastic model for spaced repetition systems. We propose a queueing network model of the Leitner system for reviewing flashcards, along with a heuristic approximation that admits a tractable optimization problem for review scheduling. Finally, we empirically evaluate our queueing model through a Mechanical Turk experiment, verifying a key qualitative prediction of our model: the existence of a sharp phase transition in learning outcomes upon increasing the rate of new item introductions.Comment: Accepted to the ACM SIGKDD Conference on Knowledge Discovery and Data Mining 201

Accidental Father-to-Son HIV-1 Transmission During the Seroconversion Period

A 4-year-old child born to an HIV-1 seronegative mother was diagnosed with HIV-1, the main risk factor being transmission from the child's father who was seroconverting at the time of the child's birth. In the context of a forensic investigation, we aimed to identify the source of infection of the child and date of the transmission event. Samples were collected from the father and child at two time points about 4 years after the child's birth. Partial segments of three HIV-1 genes (gag, pol, and env) were sequenced and maximum likelihood (ML) and Bayesian methods were used to determine direction and estimate date of transmission. Neutralizing antibodies were determined using a single cycle assay. Bayesian trees displayed a paraphyletic-monophyletic topology in all three genomic regions, with the father's host label at the root, which is consistent with father-to-son transmission. ML trees found similar topologies in gag and pol and a monophyletic-monophyletic topology in env. Analysis of the time of the most recent common ancestor of each HIV-1 gene population indicated that the child was infected shortly after the father. Consistent with the infection history, both father and son developed broad and potent HIV-specific neutralizing antibody responses. In conclusion, the direction of transmission implicated the father as the source of transmission. Transmission occurred during the seroconversion period when the father was unaware of the infection and was likely accidental. This case shows how genetic, phylogenetic, and serological data can contribute for the forensic investigation of HIV transmission.info:eu-repo/semantics/publishedVersio